Rasashashtra is a branch of India System of Medicines, Ayurveda. It deals with the medicinal uses of Metals, minerals, marine sources and plants. In addition to mercury, gold, silver, iron, copper, tin, lead, zinc and bell metal are used. In addition to these metals, salts and other substances such as coral, seashells, and feathers are also used. Mediicines prepared on the basis of Rasashashtra can be boon to the patients of Autoimmune disorders, Cancer, Skin related issues, ageing, neuromuscular disorders and what not. This ppt is introduction to wonderful ancient wisdom about Medicinal chemistry. It was presented by Dr. Joban Modha during National meet on Ayurveda, In November 2009, at Tokyo, Japan as Key Note Speech.