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Targeted Drug Delivery LIPOSOMES

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Danish Kurien
Danish Kurien
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Targeted Drug Delivery System LIPOSOMES
Learning Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What are Liposomes? ,[object Object]
[object Object],[object Object],[object Object]
Advantages of liposome : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disadvantages of liposome : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liposomes Evolution : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanism of liposome formation ,[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
Classification of liposomes ,[object Object],[object Object],[object Object],[object Object]
 
Materials used in preparation of liposomes ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object]
Methods of liposomes preparations Passive loading technique Active loading technique Mechanical dispersion methods Solvent dispersion methods Detergent removal methods
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physical Characterization Surface charge Free-flow electrophoresis Electrical surface potential and surface pH Zetapotential measurements & pH sensitive probes Percent of free drug/ percent capture Drug release Diffusion cell/ dialysis Parameter Characterization method Vesicle shape and surface morphology Mean vesicle size and size distribution Dynamic light scattering, zetasizer, Photon correlation spectroscopy, laser light scattering, gel permeation and gel exclusion Minicolumn centrifugation, ion-exchange chromatography,  radiolabelling Transmission electron microscopy, Freeze-fracture electron microscopy
Phopholipid peroxidation UV absorbance, Iodometric  and GLC Phospholipid hydrolysis, Cholesterol auto-oxidation HPLC and TLC Osmolarity Parameter Characterization method Phospholipid concentration Cholesterol concentration Cholesterol oxidase assay and HPLC Osmometer Barlett assay, stewart assay, HPLC Chemical Characterization
Biological Characterization Animal toxicity Monitoring survival rates, histology and pathology Parameter Characterization method Sterility Pyrogenicity Limulus Amebocyte Lysate (LAL) test Aerobic or anaerobic cultures
Stability ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Therapeutic applications of liposomes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pseudomonas infection, aeruginosa Pulmonary delivery Tobramycin Asthma Pulmonary delivery Pentoxyfylline Pain muscle condition Ocular delivery   Ketoprofen Diabetic mellitus Oral, Ocular, Pulmonary and Transdermal delivery   Insulin Mycotic infection Oral delivery Amphotericin-B Targeted Diseases Route of administration Drug
Cancer Transdermal Methotrexate Meningococal, staphylococcal Pulmonary delivery Penicillin G Glucoma, Conjectivitis Ocular delivery Adrenaline Rheumatoid arthritis Oral delivery Ibuprofen ulcer on mucous surface with pain Transdermal Benzocain Asthma Pulmonary delivery Salbutamol Targeted Diseases Route of administration Drug
Britannia Pharm, UK Expanding lung diseases in babies Dry protein free powder of DPPC-PG ALECTM The liposome company, USA Systemic inflammatory diseases Prostaglandin-E1 VENTUSTM SEQUUS, USA fungal infections, Leishmaniasis Amphotericin-B AmphotecTM NeXstar, USA Kaposi’s sarcoma, breast & lung cancer Daunorubicin DaunoXomeTM SEQUUS, USA Kaposi’s sarcoma Doxorubicin DoxilTM or CaelyxTM Company Target diseases Drug used Marketed product
Swiss serum & vaccine institute, Switzerland Hepatitis A Inactivated hepatitis-A Virions Epaxal –Berna Vaccine Vineland lab, USA Chicken pox Killed avian retrovirus Avian retrovirus vaccine Novavax, USA Smallpox Smallpox vaccine Novasome® Skye Pharm, USA Cancer therapy Cytarabine Depocyt Ozone, USA Asthma Terbutaline sulphate Topex-Br Company Target diseases Drug used Marketed product
Conclusion ,[object Object],[object Object],[object Object]
Reference ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Any question...
Thank You

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Targeted Drug Delivery LIPOSOMES

  • 1. Targeted Drug Delivery System LIPOSOMES
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.  
  • 14.
  • 15.  
  • 16.
  • 17. Methods of liposomes preparations Passive loading technique Active loading technique Mechanical dispersion methods Solvent dispersion methods Detergent removal methods
  • 18.
  • 19.
  • 20. Physical Characterization Surface charge Free-flow electrophoresis Electrical surface potential and surface pH Zetapotential measurements & pH sensitive probes Percent of free drug/ percent capture Drug release Diffusion cell/ dialysis Parameter Characterization method Vesicle shape and surface morphology Mean vesicle size and size distribution Dynamic light scattering, zetasizer, Photon correlation spectroscopy, laser light scattering, gel permeation and gel exclusion Minicolumn centrifugation, ion-exchange chromatography,  radiolabelling Transmission electron microscopy, Freeze-fracture electron microscopy
  • 21. Phopholipid peroxidation UV absorbance, Iodometric  and GLC Phospholipid hydrolysis, Cholesterol auto-oxidation HPLC and TLC Osmolarity Parameter Characterization method Phospholipid concentration Cholesterol concentration Cholesterol oxidase assay and HPLC Osmometer Barlett assay, stewart assay, HPLC Chemical Characterization
  • 22. Biological Characterization Animal toxicity Monitoring survival rates, histology and pathology Parameter Characterization method Sterility Pyrogenicity Limulus Amebocyte Lysate (LAL) test Aerobic or anaerobic cultures
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28. Pseudomonas infection, aeruginosa Pulmonary delivery Tobramycin Asthma Pulmonary delivery Pentoxyfylline Pain muscle condition Ocular delivery   Ketoprofen Diabetic mellitus Oral, Ocular, Pulmonary and Transdermal delivery   Insulin Mycotic infection Oral delivery Amphotericin-B Targeted Diseases Route of administration Drug
  • 29. Cancer Transdermal Methotrexate Meningococal, staphylococcal Pulmonary delivery Penicillin G Glucoma, Conjectivitis Ocular delivery Adrenaline Rheumatoid arthritis Oral delivery Ibuprofen ulcer on mucous surface with pain Transdermal Benzocain Asthma Pulmonary delivery Salbutamol Targeted Diseases Route of administration Drug
  • 30. Britannia Pharm, UK Expanding lung diseases in babies Dry protein free powder of DPPC-PG ALECTM The liposome company, USA Systemic inflammatory diseases Prostaglandin-E1 VENTUSTM SEQUUS, USA fungal infections, Leishmaniasis Amphotericin-B AmphotecTM NeXstar, USA Kaposi’s sarcoma, breast & lung cancer Daunorubicin DaunoXomeTM SEQUUS, USA Kaposi’s sarcoma Doxorubicin DoxilTM or CaelyxTM Company Target diseases Drug used Marketed product
  • 31. Swiss serum & vaccine institute, Switzerland Hepatitis A Inactivated hepatitis-A Virions Epaxal –Berna Vaccine Vineland lab, USA Chicken pox Killed avian retrovirus Avian retrovirus vaccine Novavax, USA Smallpox Smallpox vaccine Novasome® Skye Pharm, USA Cancer therapy Cytarabine Depocyt Ozone, USA Asthma Terbutaline sulphate Topex-Br Company Target diseases Drug used Marketed product
  • 32.
  • 33.
  • 34.