CorDynamics adds a powerful capability to its leading suite of pulmonary arterial hypertension models – the ability to record pulmonary artery pressures in the rat.

1. CorDynamics adds a powerful capability to its leading suite of
pulmonary arterial hypertension models – the ability to record
pulmonary artery pressures in the rat
Multiple options
1) single pressure OR dual pressure
- for differential effects on both arterial beds
2) increased frequency of pulmonary artery pressure readings
- characterize development of PAH
- critical to test efficacy in prevention AND reversal mode
- design studies with more efficiency

2. Telemetry pressure catheter was placed into pulmonary artery via
right ventricle
- animals were allowed to recover, administered SU5416, then placed
in low oxygen environment
- low technical failure rate
Clinical observations consistent with development of strong
pulmonary hypertension
- At Day 42, 438% increase in pulmonary artery pressure vs. baseline
- at Day 42, animals euthanized and robust RV hypertrophy confirmed
- mean RV/LV+S ratio was .624 ± .079; normal = ~ .300

3. Telemetered Hemodynamic Evaluation of Vehicle Administration in the Rat
Pulmonary Arterial Hypertension Model Induced with Semaxanib (Day 1) and a Low
Oxygen Environment - Systolic Pulmonary Artery Pressure
180
160
140
120
(mm Hg)
100
80
60
40
Vehicle
20
0
-5 0 5 10 15 20 25 30 35 40 45
Days of Hypoxia