This document discusses a comprehensive dataset that demonstrates the effect of multiple positive controls on hemodynamics and electrocardiography using limited quantities of test articles while maintaining throughput amenable for screening, allowing pharmacokinetic-pharmacodynamic relationships to be established.

1. Comprehensive dataset demonstrating effect of
multiple positive controls on hemodynamics and
electrocardiography
- throughput amenable for screening
- uses limited quantities of test article
- PK-PD can be established