Nitric oxide is a molecule that plays an important role in various biological systems like the nervous, cardiovascular, and immune systems. It is involved in cellular signaling as a paracrine and autocrine molecule. Nitric oxide acts as a vasodilator by signaling smooth muscle in blood vessels to relax, increasing blood flow. Foods high in nitrates like beets, spinach, and watermelon can increase nitric oxide levels and lower blood pressure. Icariin supplements are effective natural boosters of nitric oxide that improve exercise performance and muscle recovery.

1. What Is Nitric Oxide?
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2.  Despite being a simple molecule, NITRIC
OXIDE (NO) is an important biological
regulator and plays an important role in
 Neuroscience
 Physiology and Sport science
 Immunology
Nitric Oxide
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3.  Nitric Oxide is a free radical
 It’s bonding structure includes an
unpaired electron
Nitric Oxide (NO)
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4.  When NO is exposed to oxygen, NO is converted into nitrogen
dioxide
 2 NO + O2  2 NO2
 In water, NO reacts with oxygen and water to form HNO2 or
nitrous acid
 4 NO + O2 + 2 H2O  4 HNO2
Nitric Oxide and Oxygen
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5.  Nitric Oxide is an important cellular signaling molecule
 involved in many physiological and pathological processes
 NO is highly reactive, having a life time of a few seconds in the
blood, and diffuses freely across cell membranes
 This makes NO ideal for a transient paracrine (between adjacent
cells) and autocrine (with in a single cell) signaling molecule
What does Nitric Oxide do?
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6.  Nitric Oxide is a powerful vasodilator
 Nitric Oxide is also known as the “endothelium-derived
relaxing factor” (EDRF)
 The endothelium (inner layer) of blood vessels uses NO to
signal the surrounding smooth muscle to relax
 Resulting in vasodilation and increased blood flow
What does Nitric Oxide do?
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7.  Effects include vasodilatation, neurotransmission, production of
reactive nitrogen intermediates and penile erections
 Nitroglycerin and amyl nitrite serve as vasodilators because they are
converted to NO in the body
 Minoxidil, a vasodilating antihypertensive drug, contains an NO moiety
and may act as an NO agonist
 Sildenafil and icariin stimulates erections primarily by enhancing
signaling through the NO pathway in the penis
Nitric Oxide production
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8.  Dark chocolate
 Increases NO production and lowers blood pressure
 Watermelon
 Contains amino acid L-Citrulline (one of the best natural
compounds to increase NO)
 Pomegranate
 Boosts NO production and testosterone levels
Nitrate rich food
You can increase cardio protective levels of NO with a corresponding
reduction in blood pressure by eating right

9.  Walnuts
 Increases testosterone levels
 Packed with vitamin E (strengthens arteries)
 Can help lower blood pressure
 Spinach
 Has one of the highest nitrate contents of all plants
 Oranges
 Vitamin C helps protect NO molecules from free radicals
Nitrate rich food
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10.  Beet Root
 Has one of the highest nitrate count in all of plants
 Can lower your estrogen levels
 Cranberries
 Increase nitric oxide production
 Can lower blood pressure significantly
 Horny Goat Weed
 Increases nitric oxide production and levels of free circulating
testosterone
 Acts as a natural PDE-5 inhibitor
Nitrate rich food
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11.  Icariin extracts are one of the best NATURAL nitric oxide
boosters on the supplement market today
 The higher the purity of the extracts the higher the effects
 Helps ensure the efficient supply of nutrients through the
blood flow
 Massively improving workout performance, resistance to fatigue
and helps muscles to recover
Icariin
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