06.05.08 Invited Talk Health Science Advisory Board Title: Microbial Metagenomics and Human Health La Jolla, CA

1. Microbial Metagenomics and Human Health Invited Talk Health Sciences Advisory Board School of Medicine University of California, San Diego May 8, 2006 Dr. Larry Smarr Director, California Institute for Telecommunications and Information Technologies Harry E. Gruber Professor, Dept. of Computer Science and Engineering Jacobs School of Engineering, UCSD

3. Evolution is the Principle of Biological Systems: Most of Evolutionary Time Was in the Microbial World Source: Carl Woese, et al You Are Here Much of Genome Work Has Occurred in Animals

5. PI Larry Smarr Announced January 17, 2006 $24.5M Over Seven Years

6. Marine Genome Sequencing Project Measuring the Genetic Diversity of Ocean Microbes CAMERA will include All Sorcerer II Metagenomic Data

7. First Implementation of the CAMERA Complex– 1/10 of Final Scale Compute Database & Storage

10. The Human Genome Is Vastly More Complicated than Microbial Genomes Russell Dolittle, Nature v.419, p. 494 (2002) Microbes (3.3 Billion Bases) (1.8 Million Bases) 10 6 10 7 10 8 10 5 10 9 10 10 DNA Base Pairs

12. The Human Kinome Manning, et al (2002) Science 298 :1912 Over 500 Protein Kinases 2% of the Human Genome Many splice variants Source: Susan Taylor, SOM, UCSD

14. The Human Kinome is a Small Part of the Kinome Tree Across All Living Creatures Identified 15,000 New Kinases In Venter Global Ocean Sampling Data Defines the Evolution of the Eukaryotic Protein Kinases Human Kinome Source: Susan Taylor, SOM, UCSD

15. The Human Kinome: 3D Protein Structures Crystal Structures Source: Susan Taylor, SOM, UCSD

16. 3D Kinase Protein Structures That are Implicated in Disease Source: Susan Taylor, SOM, UCSD The Anti-Cancer Drug Gleevac Targets abl IRK CKI PhosK cdk2 PKA PKA abl Insulin Receptor ( Diabetes ) Leukemias/Sarcomas ( Cancer ) Conserved Fold Cell cycle Muscle contraction Circadian Rhythm HIV Heart Disease

18. Interactive Visualization of Thermatoga Proteins at Calit2 Source: John Wooley, Jurgen Schulze, Calit2

19. End Users Can Direct Connect to CAMERA Using Lambdas--Individual 1 or 10Gbps Dedicated Lightpaths ( WDM) Source: Steve Wallach, Chiaro Networks “ Lambdas”

20. National Lambda Rail (NLR) and TeraGrid Provides Cyberinfrastructure Backbone for U.S. Researchers NLR 4 x 10Gb Lambdas Initially Capable of 40 x 10Gb wavelengths at Buildout Links Two Dozen State and Regional Optical Networks DOE, NSF, & NASA Using NLR San Francisco Pittsburgh Cleveland San Diego Los Angeles Portland Seattle Pensacola Baton Rouge Houston San Antonio Las Cruces / El Paso Phoenix New York City Washington, DC Raleigh Jacksonville Dallas Tulsa Atlanta Kansas City Denver Ogden/ Salt Lake City Boise Albuquerque UC-TeraGrid UIC/NW-Starlight Chicago International Collaborators NSF’s TeraGrid Has 4 x 10Gb Lambda Backbone

21. Calit2’s Direct Access Core Architecture Will Create Next Generation Metagenomics Server Source: Phil Papadopoulos, SDSC, Calit2 + Web Services User Environment CAMERA Complex Flat File Server Farm TeraGrid Backplane (10000s of CPUs) W E B PORTAL Web Local Cluster Direct Access Lambda Cnxns Dedicated Compute Farm (1000 CPUs) Data- Base Farm 10 GigE Fabric

22. Combining High Definition Video Streams with Large Scale Image Display Walls Source: David Lee, NCMIR, UCSD Large Scale Images of He-La Cancer Cells

23. Calit2 and the Venter Institute Will Combine Telepresence with Remote Interactive Analysis Live Demonstration of 21st Century National-Scale Team Science OptIPuter Visualized Data HDTV Over Lambda 25 Miles Venter Institute