SlideShare ist ein Scribd-Unternehmen logo
1 von 11
Downloaden Sie, um offline zu lesen
Precision Medicine:Precision Medicine:
a revolution in research, health anda revolution in research, health and
health care driven by informaticshealth care driven by informatics
Keith YamamotoKeith Yamamoto
keith.yamamoto@ucsf.edukeith.yamamoto@ucsf.edu
UCSF Informatics DayUCSF Informatics Day
June 10, 2014June 10, 2014
Biomedical & clininal research at an inflection pointBiomedical & clininal research at an inflection point
datadata collection,collection,
detaileddetailed description,description,
“imprecise medicine”“imprecise medicine”
mechanisticmechanistic understandingunderstanding ofof
biological processes,biological processes, precisionprecision
medicinemedicine
How move through the inflection point?How move through the inflection point?
• Merge sciences:Merge sciences: incorporate concepts and technologies ofincorporate concepts and technologies of
physical sciences, engineering, computer science, informaticsphysical sciences, engineering, computer science, informatics
• Build working continuum:Build working continuum: from fundamental discovery, tofrom fundamental discovery, to
application, to addressing health and diseaseapplication, to addressing health and disease
Integrate practices and policies across three planesIntegrate practices and policies across three planes
computation
computation
governmentgovernment
industry
industry
ngo
ngo
academia
academia
clinicalclinical
engineeringengineering
chemistry
chemistry
physics
physics Biomedical continuum:Biomedical continuum:
Build seamless links betweenBuild seamless links between
basic discovery, translation,basic discovery, translation,
clinical care, patients, citizensclinical care, patients, citizens
Transdisciplinary science:Transdisciplinary science:
MergeMerge
physics/chemistry/engineering/cphysics/chemistry/engineering/c
omputationomputation
theory, concepts, methods intotheory, concepts, methods into
biomedical researchbiomedical research
Stakeholder synergy:Stakeholder synergy:
Cooperate acrossCooperate across
.edu, .com, .gov and .org.edu, .com, .gov and .org
Goal: Precision MedicineGoal: Precision Medicine
Imprecise Medicine: Where we are nowImprecise Medicine: Where we are now
What is a disease gene? If I have one, why does it only changeWhat is a disease gene? If I have one, why does it only change
thethe “risk”, sometimes by tiny amounts, that I will get the disease?“risk”, sometimes by tiny amounts, that I will get the disease?
Why is disease diagnosis so far from an exact science?Why is disease diagnosis so far from an exact science?
How could gathering more information about me, about otherHow could gathering more information about me, about other
people, about mice, flies and yeast, make my health better?people, about mice, flies and yeast, make my health better?
““Normal” biology is complicated:Normal” biology is complicated:
-- we don’t know mechanisms-- we don’t know mechanisms
-- controlled by intersecting,-- controlled by intersecting,
multistep signaling networksmultistep signaling networks
-- highly context dependent, altered by many variables-- highly context dependent, altered by many variables
Therefore,Therefore, diseasedisease,, as a deviation fromas a deviation from healthhealth, is similarly complex., is similarly complex.
We need an integrated understanding of mechanisms.We need an integrated understanding of mechanisms.
Precision Medicine: Defined and ComparedPrecision Medicine: Defined and Compared
Personalized medicine:Personalized medicine:
Collect and analyze extensive information and data aboutCollect and analyze extensive information and data about
patient, EHR to genome and beyond; physician uses thispatient, EHR to genome and beyond; physician uses this
information and data to make more informed diagnosis andinformation and data to make more informed diagnosis and
treatment plantreatment plan
Current medical practice:Current medical practice:
Use vital signs today relative to last visit (EHR?); assessUse vital signs today relative to last visit (EHR?); assess
symptoms; physician uses expert background, experience andsymptoms; physician uses expert background, experience and
judgment to diagnose, prescribejudgment to diagnose, prescribe
Precision medicine:Precision medicine:
Use massive data network that aggregates and analyzesUse massive data network that aggregates and analyzes
information from huge patient cohorts, healthy populations,information from huge patient cohorts, healthy populations,
experimental organisms– and reaches toward diseaseexperimental organisms– and reaches toward disease
mechanisms, and precision diagnosis and treatment for eachmechanisms, and precision diagnosis and treatment for each
individualindividual
Integrate rapidly expanding range and detail of biological,Integrate rapidly expanding range and detail of biological,
clinical, behavioral and experiential information to:clinical, behavioral and experiential information to:
• drive basic discovery with new syntheses and hypothesesdrive basic discovery with new syntheses and hypotheses
• promote the development of a more accurate and precisepromote the development of a more accurate and precise
classification of diseaseclassification of disease
• advance speed and accuracy of diagnosis, therapy and cureadvance speed and accuracy of diagnosis, therapy and cure
Building a research and health continuumBuilding a research and health continuum
An enabling toolAn enabling tool
Build anBuild an “Information Commons”“Information Commons”
and “Knowledge Network” toand “Knowledge Network” to
correlate and align disparatecorrelate and align disparate
information, motivate researchinformation, motivate research
team-building, convene allteam-building, convene all
stakeholders, including patients,stakeholders, including patients,
into a dynamic researchinto a dynamic research
ecosystemecosystem
TOWARD PRECISION
MEDICINE
  Board on Life SciencesBoard on Life Sciences
  http://www.nap.edu/catalog.php?record_id=13284http://www.nap.edu/catalog.php?record_id=13284
Building a Knowledge Network for
Biomedical Research and a New
Taxonomy of Disease
Precision MedicinePrecision Medicine
Geographical Information Systems and
a biomedical information commons
EHREHR
Population studiesPopulation studies
New DiagnosesNew Diagnoses
New Therapy ImplicationsNew Therapy Implications
New Health OutcomesNew Health Outcomes
New CorrelationsNew Correlations
New HypothesesNew Hypotheses
New Transdisciplinary LinksNew Transdisciplinary Links
KnowledgeKnowledge
NetworkNetwork
BasicBasic
DiscoveryDiscovery
ClinicalClinical
DiscoveryDiscovery
ComputationalComputational
Health ScienceHealth Science Digital HealthDigital Health
OmicOmic
MedicineMedicine
InformationInformation
CommonsCommons
Patients &Patients &
CitizensCitizens
New knowledgeNew knowledge
UCSF Precision MedicineUCSF Precision Medicine
Platform &Platform &
Outreach CoreOutreach Core
• Nucleate in neurological
disease and cancer; rapid
spread will encompass all areas
• Build integrated, visualizable access to basic,
translational, clinical, population data
• Converge expertise and infrastructure resources of
computer scientists, bioinformaticians, commercial
partners, national lab, clinical and basic scientists
UCSF Knowledge NetworkUCSF Knowledge Network
• Big dataBig data
• Diverse data types:Diverse data types: e.g., -omics, imaging (e.g., cryoEM,e.g., -omics, imaging (e.g., cryoEM,
brain activity, longitudinal MRI), EHR, population studies,brain activity, longitudinal MRI), EHR, population studies,
environmental effectsenvironmental effects
• Digital health:Digital health: wearable sensors, reporterswearable sensors, reporters
• Data acquisition, aggregation, integration, analysisData acquisition, aggregation, integration, analysis
• Continuous learningContinuous learning
• Data storage, security, selective accessData storage, security, selective access
• Data sorting and visualizationData sorting and visualization
Computational/informatics challenges  Computational/informatics challenges  
•A research ecosystem that informs, integratesA research ecosystem that informs, integrates
basic, clinical, population data, and includesbasic, clinical, population data, and includes
allall
stakeholder sectorsstakeholder sectors
•Health and healthcare tailored to the individualHealth and healthcare tailored to the individual
•Reduced healthcare costsReduced healthcare costs
Precision medicine outcomesPrecision medicine outcomes
Five of the world’s twenty leading academic biosciencesFive of the world’s twenty leading academic biosciences
institutions are located here in California: UCSF, Berkeley,institutions are located here in California: UCSF, Berkeley,
UCLA, Stanford and UC San Diego. Just as California ledUCLA, Stanford and UC San Diego. Just as California led
the way with stem cell research, so too can we pioneerthe way with stem cell research, so too can we pioneer
the new field of precision medicine which uses genomes,the new field of precision medicine which uses genomes,
medical devices, computer sciences and other fields tomedical devices, computer sciences and other fields to
treat individual patients instead of broad populations.treat individual patients instead of broad populations.
California Gov Jerry BrownCalifornia Gov Jerry Brown
2014 State of the State Address2014 State of the State Address

Weitere ähnliche Inhalte

Was ist angesagt?

Clinical Genomics and Medicine
Clinical Genomics and MedicineClinical Genomics and Medicine
Clinical Genomics and MedicineWarren Kibbe
 
MT115 Precision Medicine: Integrating genomics to enable better patient outcomes
MT115 Precision Medicine: Integrating genomics to enable better patient outcomesMT115 Precision Medicine: Integrating genomics to enable better patient outcomes
MT115 Precision Medicine: Integrating genomics to enable better patient outcomesDell EMC World
 
Transforming the NHS through genomic and personalised medicine, pop up uni, 1...
Transforming the NHS through genomic and personalised medicine, pop up uni, 1...Transforming the NHS through genomic and personalised medicine, pop up uni, 1...
Transforming the NHS through genomic and personalised medicine, pop up uni, 1...NHS England
 
Modern Genomics in conjunction with Patients IP on the value chain
Modern Genomics in conjunction with Patients IP on the value chainModern Genomics in conjunction with Patients IP on the value chain
Modern Genomics in conjunction with Patients IP on the value chainJohn Peter Mary Wubbe
 
Precision medicine the future of_healthcare
Precision medicine  the future of_healthcarePrecision medicine  the future of_healthcare
Precision medicine the future of_healthcareThomas Wilckens
 
Towards Digitally Enabled Genomic Medicine: the Patient of The Future
Towards Digitally Enabled Genomic Medicine: the Patient of The FutureTowards Digitally Enabled Genomic Medicine: the Patient of The Future
Towards Digitally Enabled Genomic Medicine: the Patient of The FutureLarry Smarr
 
Paradigmshift in precision medicine
Paradigmshift in precision medicineParadigmshift in precision medicine
Paradigmshift in precision medicineAlex Beer
 
InnVentis Precision Medicine 2014
InnVentis  Precision Medicine 2014InnVentis  Precision Medicine 2014
InnVentis Precision Medicine 2014Thomas Wilckens
 
EuroBioForum2014_speaker_Manolio
EuroBioForum2014_speaker_ManolioEuroBioForum2014_speaker_Manolio
EuroBioForum2014_speaker_ManolioEuroBioForum
 
The Uneven Future of Evidence-Based Medicine
The Uneven Future of Evidence-Based MedicineThe Uneven Future of Evidence-Based Medicine
The Uneven Future of Evidence-Based MedicineIda Sim
 
BioData West 2017 Brochure.PDF
BioData West 2017 Brochure.PDFBioData West 2017 Brochure.PDF
BioData West 2017 Brochure.PDFMichael Shackil
 
UK Biobank: A Prospective Cohort Epidemiology Study
UK Biobank: A Prospective Cohort Epidemiology StudyUK Biobank: A Prospective Cohort Epidemiology Study
UK Biobank: A Prospective Cohort Epidemiology Studyamirhannan
 
Khoury ashg2014
Khoury ashg2014Khoury ashg2014
Khoury ashg2014muink
 
EuroBioForum2014_sepaker_Palotie
EuroBioForum2014_sepaker_PalotieEuroBioForum2014_sepaker_Palotie
EuroBioForum2014_sepaker_PalotieEuroBioForum
 

Was ist angesagt? (20)

Integrated health monitoring
Integrated health monitoringIntegrated health monitoring
Integrated health monitoring
 
Clinical Genomics and Medicine
Clinical Genomics and MedicineClinical Genomics and Medicine
Clinical Genomics and Medicine
 
The Precision Medicine Revolution (Geoffrey Ginsburg)
The Precision Medicine Revolution (Geoffrey Ginsburg)The Precision Medicine Revolution (Geoffrey Ginsburg)
The Precision Medicine Revolution (Geoffrey Ginsburg)
 
Fjms - keynote at MIE 2015
Fjms - keynote at MIE 2015Fjms - keynote at MIE 2015
Fjms - keynote at MIE 2015
 
MT115 Precision Medicine: Integrating genomics to enable better patient outcomes
MT115 Precision Medicine: Integrating genomics to enable better patient outcomesMT115 Precision Medicine: Integrating genomics to enable better patient outcomes
MT115 Precision Medicine: Integrating genomics to enable better patient outcomes
 
Transforming the NHS through genomic and personalised medicine, pop up uni, 1...
Transforming the NHS through genomic and personalised medicine, pop up uni, 1...Transforming the NHS through genomic and personalised medicine, pop up uni, 1...
Transforming the NHS through genomic and personalised medicine, pop up uni, 1...
 
Modern Genomics in conjunction with Patients IP on the value chain
Modern Genomics in conjunction with Patients IP on the value chainModern Genomics in conjunction with Patients IP on the value chain
Modern Genomics in conjunction with Patients IP on the value chain
 
Precision medicine the future of_healthcare
Precision medicine  the future of_healthcarePrecision medicine  the future of_healthcare
Precision medicine the future of_healthcare
 
Towards Digitally Enabled Genomic Medicine: the Patient of The Future
Towards Digitally Enabled Genomic Medicine: the Patient of The FutureTowards Digitally Enabled Genomic Medicine: the Patient of The Future
Towards Digitally Enabled Genomic Medicine: the Patient of The Future
 
Intro: California Initiative to Advance Precision Medicine Workshop
Intro: California Initiative to Advance Precision Medicine WorkshopIntro: California Initiative to Advance Precision Medicine Workshop
Intro: California Initiative to Advance Precision Medicine Workshop
 
Paradigmshift in precision medicine
Paradigmshift in precision medicineParadigmshift in precision medicine
Paradigmshift in precision medicine
 
InnVentis Precision Medicine 2014
InnVentis  Precision Medicine 2014InnVentis  Precision Medicine 2014
InnVentis Precision Medicine 2014
 
Integrating Genomic Medicine into Patient Care with Trish Brown, MS, CGC
Integrating Genomic Medicine into Patient Care with Trish Brown, MS, CGCIntegrating Genomic Medicine into Patient Care with Trish Brown, MS, CGC
Integrating Genomic Medicine into Patient Care with Trish Brown, MS, CGC
 
EuroBioForum2014_speaker_Manolio
EuroBioForum2014_speaker_ManolioEuroBioForum2014_speaker_Manolio
EuroBioForum2014_speaker_Manolio
 
The Uneven Future of Evidence-Based Medicine
The Uneven Future of Evidence-Based MedicineThe Uneven Future of Evidence-Based Medicine
The Uneven Future of Evidence-Based Medicine
 
BioData West 2017 Brochure.PDF
BioData West 2017 Brochure.PDFBioData West 2017 Brochure.PDF
BioData West 2017 Brochure.PDF
 
UK Biobank: A Prospective Cohort Epidemiology Study
UK Biobank: A Prospective Cohort Epidemiology StudyUK Biobank: A Prospective Cohort Epidemiology Study
UK Biobank: A Prospective Cohort Epidemiology Study
 
Khoury ashg2014
Khoury ashg2014Khoury ashg2014
Khoury ashg2014
 
EuroBioForum2014_sepaker_Palotie
EuroBioForum2014_sepaker_PalotieEuroBioForum2014_sepaker_Palotie
EuroBioForum2014_sepaker_Palotie
 
Atul Butte presentation at the Morris Collen 100 birthday celebration
Atul Butte presentation at the Morris Collen 100 birthday celebrationAtul Butte presentation at the Morris Collen 100 birthday celebration
Atul Butte presentation at the Morris Collen 100 birthday celebration
 

Andere mochten auch

CER 2016 Srivastava
CER 2016 Srivastava CER 2016 Srivastava
CER 2016 Srivastava CTSI at UCSF
 
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...CTSI at UCSF
 
CER 2016 Phillips cer symposium pcori 2016 from 012716
CER 2016 Phillips cer symposium pcori 2016 from 012716CER 2016 Phillips cer symposium pcori 2016 from 012716
CER 2016 Phillips cer symposium pcori 2016 from 012716CTSI at UCSF
 
CER 2016 Trontell pcori cer presentation 2016 02 02 final
CER 2016 Trontell pcori cer presentation 2016 02 02 finalCER 2016 Trontell pcori cer presentation 2016 02 02 final
CER 2016 Trontell pcori cer presentation 2016 02 02 finalCTSI at UCSF
 
UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...
UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...
UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...CTSI at UCSF
 
Health research, clinical registries, electronic health records – how do they...
Health research, clinical registries, electronic health records – how do they...Health research, clinical registries, electronic health records – how do they...
Health research, clinical registries, electronic health records – how do they...Koray Atalag
 
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...CTSI at UCSF
 
CER 2016 Dohan EQUIP
CER 2016 Dohan EQUIPCER 2016 Dohan EQUIP
CER 2016 Dohan EQUIPCTSI at UCSF
 
CER 2016 Nguyen ctsi collaborative research
CER 2016 Nguyen ctsi collaborative researchCER 2016 Nguyen ctsi collaborative research
CER 2016 Nguyen ctsi collaborative researchCTSI at UCSF
 
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15CTSI at UCSF
 
CER 2016 Goldman Intro
CER 2016 Goldman IntroCER 2016 Goldman Intro
CER 2016 Goldman IntroCTSI at UCSF
 
CER 2016 Jacoby stakeholder engagement
CER 2016 Jacoby stakeholder engagementCER 2016 Jacoby stakeholder engagement
CER 2016 Jacoby stakeholder engagementCTSI at UCSF
 
UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...
UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...
UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...CTSI at UCSF
 
UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...
UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...
UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...CTSI at UCSF
 
UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"
UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"
UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"CTSI at UCSF
 
CER 2016 Hernandez patient engagement
CER 2016 Hernandez patient engagementCER 2016 Hernandez patient engagement
CER 2016 Hernandez patient engagementCTSI at UCSF
 
UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...
UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...
UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...CTSI at UCSF
 
Building Your Professional Network with LinkedIn
Building Your Professional Network with LinkedInBuilding Your Professional Network with LinkedIn
Building Your Professional Network with LinkedInCTSI at UCSF
 
CER 2016 Goldman CTSI CER Resources
CER 2016 Goldman CTSI CER ResourcesCER 2016 Goldman CTSI CER Resources
CER 2016 Goldman CTSI CER ResourcesCTSI at UCSF
 
UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"
UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"
UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"CTSI at UCSF
 

Andere mochten auch (20)

CER 2016 Srivastava
CER 2016 Srivastava CER 2016 Srivastava
CER 2016 Srivastava
 
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...
VIVO 2014: Google Analytics, Email Marketing & Vanity to Increase User Engage...
 
CER 2016 Phillips cer symposium pcori 2016 from 012716
CER 2016 Phillips cer symposium pcori 2016 from 012716CER 2016 Phillips cer symposium pcori 2016 from 012716
CER 2016 Phillips cer symposium pcori 2016 from 012716
 
CER 2016 Trontell pcori cer presentation 2016 02 02 final
CER 2016 Trontell pcori cer presentation 2016 02 02 finalCER 2016 Trontell pcori cer presentation 2016 02 02 final
CER 2016 Trontell pcori cer presentation 2016 02 02 final
 
UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...
UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...
UCSF Informatics Day 2014 - Priyanka Agarwal, "Center for Digital Health Inno...
 
Health research, clinical registries, electronic health records – how do they...
Health research, clinical registries, electronic health records – how do they...Health research, clinical registries, electronic health records – how do they...
Health research, clinical registries, electronic health records – how do they...
 
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...
How to Harness the Power of Google Analytics, Email Marketing & Vanity to Inc...
 
CER 2016 Dohan EQUIP
CER 2016 Dohan EQUIPCER 2016 Dohan EQUIP
CER 2016 Dohan EQUIP
 
CER 2016 Nguyen ctsi collaborative research
CER 2016 Nguyen ctsi collaborative researchCER 2016 Nguyen ctsi collaborative research
CER 2016 Nguyen ctsi collaborative research
 
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15
Data Reproducibility in Preclinical Discovery, Is It a Real Problem? 09/17/15
 
CER 2016 Goldman Intro
CER 2016 Goldman IntroCER 2016 Goldman Intro
CER 2016 Goldman Intro
 
CER 2016 Jacoby stakeholder engagement
CER 2016 Jacoby stakeholder engagementCER 2016 Jacoby stakeholder engagement
CER 2016 Jacoby stakeholder engagement
 
UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...
UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...
UCSF Informatics Day 2014 - Mark Pletcher, "Making EHR Data Useful for the Le...
 
UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...
UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...
UCSF Informatics Day 2014 - Elizabeth St. Lezin, "Blood Transfusion Research ...
 
UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"
UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"
UCSF Informatics Day 2014 - Dana Ludwig, "Research Data Browser"
 
CER 2016 Hernandez patient engagement
CER 2016 Hernandez patient engagementCER 2016 Hernandez patient engagement
CER 2016 Hernandez patient engagement
 
UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...
UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...
UCSF Informatics Day 2014 - Ida Sim, "Informatics Technologies: From a Data-C...
 
Building Your Professional Network with LinkedIn
Building Your Professional Network with LinkedInBuilding Your Professional Network with LinkedIn
Building Your Professional Network with LinkedIn
 
CER 2016 Goldman CTSI CER Resources
CER 2016 Goldman CTSI CER ResourcesCER 2016 Goldman CTSI CER Resources
CER 2016 Goldman CTSI CER Resources
 
UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"
UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"
UCSF Informatics Day 2014 - David Dobbs, "Enterprise Data Warehouse"
 

Ähnlich wie UCSF Informatics Day 2014 - Keith R. Yamamoto, "Precision Medicine"

Digital Health Technology: The Ultimate Patient Advocate
Digital Health Technology: The Ultimate Patient AdvocateDigital Health Technology: The Ultimate Patient Advocate
Digital Health Technology: The Ultimate Patient AdvocateDavid Lee Scher, MD
 
Medicine and the Internet of Things
Medicine and the Internet of ThingsMedicine and the Internet of Things
Medicine and the Internet of ThingsBradford Hesse
 
Pattern diagnostics 2015
Pattern diagnostics 2015Pattern diagnostics 2015
Pattern diagnostics 2015Thomas Wilckens
 
Pattern diagnostics 2015
Pattern diagnostics 2015Pattern diagnostics 2015
Pattern diagnostics 2015Thomas Wilckens
 
의료의 미래, 디지털 헬스케어: 정신의학을 중심으로
의료의 미래, 디지털 헬스케어: 정신의학을 중심으로의료의 미래, 디지털 헬스케어: 정신의학을 중심으로
의료의 미래, 디지털 헬스케어: 정신의학을 중심으로Yoon Sup Choi
 
Leverage machine learning and new technologies to enhance rwe generation and ...
Leverage machine learning and new technologies to enhance rwe generation and ...Leverage machine learning and new technologies to enhance rwe generation and ...
Leverage machine learning and new technologies to enhance rwe generation and ...Athula Herath
 
DNA and Personalized medicine
DNA and Personalized medicineDNA and Personalized medicine
DNA and Personalized medicinecancerdrg
 
Health survillence and informatics.pptx
Health survillence and informatics.pptxHealth survillence and informatics.pptx
Health survillence and informatics.pptxRichaMishra186341
 
The Learning Health System: Thinking and Acting Across Scales
The Learning Health System: Thinking and Acting Across ScalesThe Learning Health System: Thinking and Acting Across Scales
The Learning Health System: Thinking and Acting Across ScalesPhilip Payne
 
Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...
Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...
Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...Philip Bourne
 

Ähnlich wie UCSF Informatics Day 2014 - Keith R. Yamamoto, "Precision Medicine" (20)

Health Informatics and Broadband Presentation
Health Informatics and Broadband Presentation Health Informatics and Broadband Presentation
Health Informatics and Broadband Presentation
 
IBES Health and biomedical informatics
IBES  Health and biomedical informaticsIBES  Health and biomedical informatics
IBES Health and biomedical informatics
 
Digital Health Technology: The Ultimate Patient Advocate
Digital Health Technology: The Ultimate Patient AdvocateDigital Health Technology: The Ultimate Patient Advocate
Digital Health Technology: The Ultimate Patient Advocate
 
Lecture fjms ballarat 2012
Lecture fjms ballarat 2012Lecture fjms ballarat 2012
Lecture fjms ballarat 2012
 
New sources of big data for precision medicine: are we ready?
New sources of big data for precision medicine: are we ready?New sources of big data for precision medicine: are we ready?
New sources of big data for precision medicine: are we ready?
 
HISA 29 Feb 2012 - BioInformatics
HISA 29 Feb 2012 - BioInformaticsHISA 29 Feb 2012 - BioInformatics
HISA 29 Feb 2012 - BioInformatics
 
Medicine and the Internet of Things
Medicine and the Internet of ThingsMedicine and the Internet of Things
Medicine and the Internet of Things
 
Pattern diagnostics 2015
Pattern diagnostics 2015Pattern diagnostics 2015
Pattern diagnostics 2015
 
Pattern diagnostics 2015
Pattern diagnostics 2015Pattern diagnostics 2015
Pattern diagnostics 2015
 
Precision and Participatory Medicine - MEDINFO 2015 Panel on big data
Precision and Participatory Medicine - MEDINFO 2015 Panel on big dataPrecision and Participatory Medicine - MEDINFO 2015 Panel on big data
Precision and Participatory Medicine - MEDINFO 2015 Panel on big data
 
의료의 미래, 디지털 헬스케어: 정신의학을 중심으로
의료의 미래, 디지털 헬스케어: 정신의학을 중심으로의료의 미래, 디지털 헬스케어: 정신의학을 중심으로
의료의 미래, 디지털 헬스케어: 정신의학을 중심으로
 
Hesse hopkins 2015
Hesse hopkins 2015Hesse hopkins 2015
Hesse hopkins 2015
 
Ispectrum magazine #13
Ispectrum magazine #13Ispectrum magazine #13
Ispectrum magazine #13
 
Leverage machine learning and new technologies to enhance rwe generation and ...
Leverage machine learning and new technologies to enhance rwe generation and ...Leverage machine learning and new technologies to enhance rwe generation and ...
Leverage machine learning and new technologies to enhance rwe generation and ...
 
DNA and Personalized medicine
DNA and Personalized medicineDNA and Personalized medicine
DNA and Personalized medicine
 
Health survillence and informatics.pptx
Health survillence and informatics.pptxHealth survillence and informatics.pptx
Health survillence and informatics.pptx
 
Big data sharing
Big data sharingBig data sharing
Big data sharing
 
The Learning Health System: Thinking and Acting Across Scales
The Learning Health System: Thinking and Acting Across ScalesThe Learning Health System: Thinking and Acting Across Scales
The Learning Health System: Thinking and Acting Across Scales
 
Personalised and Participatory Medicine Workshop15 may 2012
Personalised and Participatory Medicine Workshop15 may 2012Personalised and Participatory Medicine Workshop15 may 2012
Personalised and Participatory Medicine Workshop15 may 2012
 
Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...
Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...
Big Data and the Promise and Pitfalls when Applied to Disease Prevention and ...
 

Mehr von CTSI at UCSF

AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...
AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...
AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...CTSI at UCSF
 
UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"
UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"
UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"CTSI at UCSF
 
UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...
UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...
UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...CTSI at UCSF
 
UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...
UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...
UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...CTSI at UCSF
 
UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"
UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"
UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"CTSI at UCSF
 
UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...
UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...
UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...CTSI at UCSF
 
UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"
UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"
UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"CTSI at UCSF
 
UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...
UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...
UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...CTSI at UCSF
 
UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...
UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...
UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...CTSI at UCSF
 
UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...
UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...
UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...CTSI at UCSF
 
UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...
UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...
UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...CTSI at UCSF
 

Mehr von CTSI at UCSF (11)

AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...
AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...
AMIA Joint Summits 2017: Building Research Data Mart from UCSF OMOP Database ...
 
UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"
UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"
UCSF Informatics Day 2014 - Jocel Dumlao, "REDCap / MyResearch"
 
UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...
UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...
UCSF Informatics Day 2014 - Lindsey Watt Alami, "Study Management throughout ...
 
UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...
UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...
UCSF Informatics Day 2014 - Robert Nussbaum, "The Genomic Medicine Initiative...
 
UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"
UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"
UCSF Informatics Day 2014 - Sayan Chatterjee, "APeX Reporting"
 
UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...
UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...
UCSF Informatics Day 2014 - Sorena Nadaf, "Translational Informatics OnCore C...
 
UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"
UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"
UCSF Informatics Day 2014 - Sam Hawgood, "Informatics at UCSF"
 
UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...
UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...
UCSF Informatics Day 2014 - Sue Dubman and Alexandra Solomon, "Innovative inf...
 
UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...
UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...
UCSF Informatics Day 2014 - Sayan Chatterjee and Jennifer Clarke, "APeX Sense...
 
UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...
UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...
UCSF Informatics Day 2014 - Wylie Burke, "Bioethical Issues in Genomics and E...
 
UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...
UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...
UCSF Informatics Day 2014 - Doug Berman, "A Brief Tour of UCSF’s Clinical Dat...
 

Kürzlich hochgeladen

M.Pharm - Question Bank - Drug Delivery Systems
M.Pharm - Question Bank - Drug Delivery SystemsM.Pharm - Question Bank - Drug Delivery Systems
M.Pharm - Question Bank - Drug Delivery SystemsSumathi Arumugam
 
Exploration Method’s in Archaeological Studies & Research
Exploration Method’s in Archaeological Studies & ResearchExploration Method’s in Archaeological Studies & Research
Exploration Method’s in Archaeological Studies & ResearchPrachya Adhyayan
 
3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...
3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...
3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...PirithiRaju
 
Basic Concepts in Pharmacology in molecular .pptx
Basic Concepts in Pharmacology in molecular  .pptxBasic Concepts in Pharmacology in molecular  .pptx
Basic Concepts in Pharmacology in molecular .pptxVijayaKumarR28
 
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky WayShiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky WaySérgio Sacani
 
biosynthesis of the cell wall and antibiotics
biosynthesis of the cell wall and antibioticsbiosynthesis of the cell wall and antibiotics
biosynthesis of the cell wall and antibioticsSafaFallah
 
Krishi Vigyan Kendras - कृषि विज्ञान केंद्र
Krishi Vigyan Kendras - कृषि विज्ञान केंद्रKrishi Vigyan Kendras - कृषि विज्ञान केंद्र
Krishi Vigyan Kendras - कृषि विज्ञान केंद्रKrashi Coaching
 
Substances in Common Use for Shahu College Screening Test
Substances in Common Use for Shahu College Screening TestSubstances in Common Use for Shahu College Screening Test
Substances in Common Use for Shahu College Screening TestAkashDTejwani
 
Main Exam Applied biochemistry final year
Main Exam Applied biochemistry final yearMain Exam Applied biochemistry final year
Main Exam Applied biochemistry final yearmarwaahmad357
 
Identification of Superclusters and Their Properties in the Sloan Digital Sky...
Identification of Superclusters and Their Properties in the Sloan Digital Sky...Identification of Superclusters and Their Properties in the Sloan Digital Sky...
Identification of Superclusters and Their Properties in the Sloan Digital Sky...Sérgio Sacani
 
001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...
001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...
001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...marwaahmad357
 
geometric quantization on coadjoint orbits
geometric quantization on coadjoint orbitsgeometric quantization on coadjoint orbits
geometric quantization on coadjoint orbitsHassan Jolany
 
Application of Foraminiferal Ecology- Rahul.pptx
Application of Foraminiferal Ecology- Rahul.pptxApplication of Foraminiferal Ecology- Rahul.pptx
Application of Foraminiferal Ecology- Rahul.pptxRahulVishwakarma71547
 
soft skills question paper set for bba ca
soft skills question paper set for bba casoft skills question paper set for bba ca
soft skills question paper set for bba caohsadfeeling
 
SCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptx
SCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptxSCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptx
SCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptxROVELYNEDELUNA3
 
Genomics and Bioinformatics basics from genome to phenome
Genomics and Bioinformatics basics from genome to phenomeGenomics and Bioinformatics basics from genome to phenome
Genomics and Bioinformatics basics from genome to phenomeAjay Kumar Mahato
 
Applied Biochemistry feedback_M Ahwad 2023.docx
Applied Biochemistry feedback_M Ahwad 2023.docxApplied Biochemistry feedback_M Ahwad 2023.docx
Applied Biochemistry feedback_M Ahwad 2023.docxmarwaahmad357
 
Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...
Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...
Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...Sérgio Sacani
 
CW marking grid Analytical BS - M Ahmad.docx
CW  marking grid Analytical BS - M Ahmad.docxCW  marking grid Analytical BS - M Ahmad.docx
CW marking grid Analytical BS - M Ahmad.docxmarwaahmad357
 
TORSION IN GASTROPODS- Anatomical event (Zoology)
TORSION IN GASTROPODS- Anatomical event (Zoology)TORSION IN GASTROPODS- Anatomical event (Zoology)
TORSION IN GASTROPODS- Anatomical event (Zoology)chatterjeesoumili50
 

Kürzlich hochgeladen (20)

M.Pharm - Question Bank - Drug Delivery Systems
M.Pharm - Question Bank - Drug Delivery SystemsM.Pharm - Question Bank - Drug Delivery Systems
M.Pharm - Question Bank - Drug Delivery Systems
 
Exploration Method’s in Archaeological Studies & Research
Exploration Method’s in Archaeological Studies & ResearchExploration Method’s in Archaeological Studies & Research
Exploration Method’s in Archaeological Studies & Research
 
3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...
3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...
3.2 Pests of Sorghum_Identification, Symptoms and nature of damage, Binomics,...
 
Basic Concepts in Pharmacology in molecular .pptx
Basic Concepts in Pharmacology in molecular  .pptxBasic Concepts in Pharmacology in molecular  .pptx
Basic Concepts in Pharmacology in molecular .pptx
 
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky WayShiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
 
biosynthesis of the cell wall and antibiotics
biosynthesis of the cell wall and antibioticsbiosynthesis of the cell wall and antibiotics
biosynthesis of the cell wall and antibiotics
 
Krishi Vigyan Kendras - कृषि विज्ञान केंद्र
Krishi Vigyan Kendras - कृषि विज्ञान केंद्रKrishi Vigyan Kendras - कृषि विज्ञान केंद्र
Krishi Vigyan Kendras - कृषि विज्ञान केंद्र
 
Substances in Common Use for Shahu College Screening Test
Substances in Common Use for Shahu College Screening TestSubstances in Common Use for Shahu College Screening Test
Substances in Common Use for Shahu College Screening Test
 
Main Exam Applied biochemistry final year
Main Exam Applied biochemistry final yearMain Exam Applied biochemistry final year
Main Exam Applied biochemistry final year
 
Identification of Superclusters and Their Properties in the Sloan Digital Sky...
Identification of Superclusters and Their Properties in the Sloan Digital Sky...Identification of Superclusters and Their Properties in the Sloan Digital Sky...
Identification of Superclusters and Their Properties in the Sloan Digital Sky...
 
001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...
001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...
001 Case Study - Submission Point_c1051231_attempt_2023-11-23-14-08-42_ABS CW...
 
geometric quantization on coadjoint orbits
geometric quantization on coadjoint orbitsgeometric quantization on coadjoint orbits
geometric quantization on coadjoint orbits
 
Application of Foraminiferal Ecology- Rahul.pptx
Application of Foraminiferal Ecology- Rahul.pptxApplication of Foraminiferal Ecology- Rahul.pptx
Application of Foraminiferal Ecology- Rahul.pptx
 
soft skills question paper set for bba ca
soft skills question paper set for bba casoft skills question paper set for bba ca
soft skills question paper set for bba ca
 
SCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptx
SCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptxSCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptx
SCIENCE 6 QUARTER 3 REVIEWER(FRICTION, GRAVITY, ENERGY AND SPEED).pptx
 
Genomics and Bioinformatics basics from genome to phenome
Genomics and Bioinformatics basics from genome to phenomeGenomics and Bioinformatics basics from genome to phenome
Genomics and Bioinformatics basics from genome to phenome
 
Applied Biochemistry feedback_M Ahwad 2023.docx
Applied Biochemistry feedback_M Ahwad 2023.docxApplied Biochemistry feedback_M Ahwad 2023.docx
Applied Biochemistry feedback_M Ahwad 2023.docx
 
Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...
Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...
Legacy Analysis of Dark Matter Annihilation from the Milky Way Dwarf Spheroid...
 
CW marking grid Analytical BS - M Ahmad.docx
CW  marking grid Analytical BS - M Ahmad.docxCW  marking grid Analytical BS - M Ahmad.docx
CW marking grid Analytical BS - M Ahmad.docx
 
TORSION IN GASTROPODS- Anatomical event (Zoology)
TORSION IN GASTROPODS- Anatomical event (Zoology)TORSION IN GASTROPODS- Anatomical event (Zoology)
TORSION IN GASTROPODS- Anatomical event (Zoology)
 

UCSF Informatics Day 2014 - Keith R. Yamamoto, "Precision Medicine"

  • 1. Precision Medicine:Precision Medicine: a revolution in research, health anda revolution in research, health and health care driven by informaticshealth care driven by informatics Keith YamamotoKeith Yamamoto keith.yamamoto@ucsf.edukeith.yamamoto@ucsf.edu UCSF Informatics DayUCSF Informatics Day June 10, 2014June 10, 2014
  • 2. Biomedical & clininal research at an inflection pointBiomedical & clininal research at an inflection point datadata collection,collection, detaileddetailed description,description, “imprecise medicine”“imprecise medicine” mechanisticmechanistic understandingunderstanding ofof biological processes,biological processes, precisionprecision medicinemedicine How move through the inflection point?How move through the inflection point? • Merge sciences:Merge sciences: incorporate concepts and technologies ofincorporate concepts and technologies of physical sciences, engineering, computer science, informaticsphysical sciences, engineering, computer science, informatics • Build working continuum:Build working continuum: from fundamental discovery, tofrom fundamental discovery, to application, to addressing health and diseaseapplication, to addressing health and disease
  • 3. Integrate practices and policies across three planesIntegrate practices and policies across three planes computation computation governmentgovernment industry industry ngo ngo academia academia clinicalclinical engineeringengineering chemistry chemistry physics physics Biomedical continuum:Biomedical continuum: Build seamless links betweenBuild seamless links between basic discovery, translation,basic discovery, translation, clinical care, patients, citizensclinical care, patients, citizens Transdisciplinary science:Transdisciplinary science: MergeMerge physics/chemistry/engineering/cphysics/chemistry/engineering/c omputationomputation theory, concepts, methods intotheory, concepts, methods into biomedical researchbiomedical research Stakeholder synergy:Stakeholder synergy: Cooperate acrossCooperate across .edu, .com, .gov and .org.edu, .com, .gov and .org Goal: Precision MedicineGoal: Precision Medicine
  • 4. Imprecise Medicine: Where we are nowImprecise Medicine: Where we are now What is a disease gene? If I have one, why does it only changeWhat is a disease gene? If I have one, why does it only change thethe “risk”, sometimes by tiny amounts, that I will get the disease?“risk”, sometimes by tiny amounts, that I will get the disease? Why is disease diagnosis so far from an exact science?Why is disease diagnosis so far from an exact science? How could gathering more information about me, about otherHow could gathering more information about me, about other people, about mice, flies and yeast, make my health better?people, about mice, flies and yeast, make my health better? ““Normal” biology is complicated:Normal” biology is complicated: -- we don’t know mechanisms-- we don’t know mechanisms -- controlled by intersecting,-- controlled by intersecting, multistep signaling networksmultistep signaling networks -- highly context dependent, altered by many variables-- highly context dependent, altered by many variables Therefore,Therefore, diseasedisease,, as a deviation fromas a deviation from healthhealth, is similarly complex., is similarly complex. We need an integrated understanding of mechanisms.We need an integrated understanding of mechanisms.
  • 5. Precision Medicine: Defined and ComparedPrecision Medicine: Defined and Compared Personalized medicine:Personalized medicine: Collect and analyze extensive information and data aboutCollect and analyze extensive information and data about patient, EHR to genome and beyond; physician uses thispatient, EHR to genome and beyond; physician uses this information and data to make more informed diagnosis andinformation and data to make more informed diagnosis and treatment plantreatment plan Current medical practice:Current medical practice: Use vital signs today relative to last visit (EHR?); assessUse vital signs today relative to last visit (EHR?); assess symptoms; physician uses expert background, experience andsymptoms; physician uses expert background, experience and judgment to diagnose, prescribejudgment to diagnose, prescribe Precision medicine:Precision medicine: Use massive data network that aggregates and analyzesUse massive data network that aggregates and analyzes information from huge patient cohorts, healthy populations,information from huge patient cohorts, healthy populations, experimental organisms– and reaches toward diseaseexperimental organisms– and reaches toward disease mechanisms, and precision diagnosis and treatment for eachmechanisms, and precision diagnosis and treatment for each individualindividual
  • 6. Integrate rapidly expanding range and detail of biological,Integrate rapidly expanding range and detail of biological, clinical, behavioral and experiential information to:clinical, behavioral and experiential information to: • drive basic discovery with new syntheses and hypothesesdrive basic discovery with new syntheses and hypotheses • promote the development of a more accurate and precisepromote the development of a more accurate and precise classification of diseaseclassification of disease • advance speed and accuracy of diagnosis, therapy and cureadvance speed and accuracy of diagnosis, therapy and cure Building a research and health continuumBuilding a research and health continuum An enabling toolAn enabling tool Build anBuild an “Information Commons”“Information Commons” and “Knowledge Network” toand “Knowledge Network” to correlate and align disparatecorrelate and align disparate information, motivate researchinformation, motivate research team-building, convene allteam-building, convene all stakeholders, including patients,stakeholders, including patients, into a dynamic researchinto a dynamic research ecosystemecosystem TOWARD PRECISION MEDICINE   Board on Life SciencesBoard on Life Sciences   http://www.nap.edu/catalog.php?record_id=13284http://www.nap.edu/catalog.php?record_id=13284 Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease Precision MedicinePrecision Medicine
  • 7. Geographical Information Systems and a biomedical information commons EHREHR Population studiesPopulation studies
  • 8. New DiagnosesNew Diagnoses New Therapy ImplicationsNew Therapy Implications New Health OutcomesNew Health Outcomes New CorrelationsNew Correlations New HypothesesNew Hypotheses New Transdisciplinary LinksNew Transdisciplinary Links KnowledgeKnowledge NetworkNetwork BasicBasic DiscoveryDiscovery ClinicalClinical DiscoveryDiscovery ComputationalComputational Health ScienceHealth Science Digital HealthDigital Health OmicOmic MedicineMedicine InformationInformation CommonsCommons Patients &Patients & CitizensCitizens New knowledgeNew knowledge UCSF Precision MedicineUCSF Precision Medicine Platform &Platform & Outreach CoreOutreach Core
  • 9. • Nucleate in neurological disease and cancer; rapid spread will encompass all areas • Build integrated, visualizable access to basic, translational, clinical, population data • Converge expertise and infrastructure resources of computer scientists, bioinformaticians, commercial partners, national lab, clinical and basic scientists UCSF Knowledge NetworkUCSF Knowledge Network
  • 10. • Big dataBig data • Diverse data types:Diverse data types: e.g., -omics, imaging (e.g., cryoEM,e.g., -omics, imaging (e.g., cryoEM, brain activity, longitudinal MRI), EHR, population studies,brain activity, longitudinal MRI), EHR, population studies, environmental effectsenvironmental effects • Digital health:Digital health: wearable sensors, reporterswearable sensors, reporters • Data acquisition, aggregation, integration, analysisData acquisition, aggregation, integration, analysis • Continuous learningContinuous learning • Data storage, security, selective accessData storage, security, selective access • Data sorting and visualizationData sorting and visualization Computational/informatics challenges  Computational/informatics challenges  
  • 11. •A research ecosystem that informs, integratesA research ecosystem that informs, integrates basic, clinical, population data, and includesbasic, clinical, population data, and includes allall stakeholder sectorsstakeholder sectors •Health and healthcare tailored to the individualHealth and healthcare tailored to the individual •Reduced healthcare costsReduced healthcare costs Precision medicine outcomesPrecision medicine outcomes Five of the world’s twenty leading academic biosciencesFive of the world’s twenty leading academic biosciences institutions are located here in California: UCSF, Berkeley,institutions are located here in California: UCSF, Berkeley, UCLA, Stanford and UC San Diego. Just as California ledUCLA, Stanford and UC San Diego. Just as California led the way with stem cell research, so too can we pioneerthe way with stem cell research, so too can we pioneer the new field of precision medicine which uses genomes,the new field of precision medicine which uses genomes, medical devices, computer sciences and other fields tomedical devices, computer sciences and other fields to treat individual patients instead of broad populations.treat individual patients instead of broad populations. California Gov Jerry BrownCalifornia Gov Jerry Brown 2014 State of the State Address2014 State of the State Address

Hinweis der Redaktion

  1. Please read:a personal appeal fromWikipedia founder Jimmy Wales Read now File:Intersecting planes.svg From Wikipedia, the free encyclopedia Jump to: navigation, search File File history File usage Global file usage Metadata Intersecting_planes.svg ‎(SVG file, nominally 360 × 324 pixels, file size: 708 B) This image rendered as PNG in other sizes: 200px, 500px, 1000px, 2000px. This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. Summary Description Intersecting planes. Redrawn from bitmap image Image:Intersecting Planes.PNG. Date 9 April 2008 Source Own work Author David Eppstein Licensing I, the copyright holder of this work, release this work into the public domain. This applies worldwide.In some countries this may not be legally possible; if so:I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. File history Click on a date/time to view the file as it appeared at that time. Date/TimeThumbnailDimensionsUserComment current04:09, 10 April 2008360 × 324 (708 B)David Eppstein{{Information |Description=Intersecting planes. Redrawn from bitmap image Image:Intersecting Planes.PNG. |Source=self-made |Date=April 9, 2008 |Author= David Eppstein |Permission= |other_versions= } File usage The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Plane (geometry) Global file usage The following other wikis use this file: Usage on ar.wikipedia.org مستو Usage on be.wikipedia.org Плоскасць Usage on ca.wikipedia.org Pla Usage on ckb.wikipedia.org ڕووتەخت Usage on fa.wikipedia.org صفحه Usage on gan.wikipedia.org 平面 Usage on hi.wikipedia.org समतल (ज्यामिति) Usage on id.wikipedia.org Bidang (geometri) Usage on kk.wikipedia.org Жазықтық (геометрия) Usage on km.wikipedia.org ប្លង់ Usage on la.wikipedia.org Planum (geometria) Usage on lt.wikipedia.org Plokštuma Usage on lv.wikipedia.org Plakne Usage on mk.wikipedia.org Рамнина (математика) Usage on nn.wikipedia.org Plan i matematikk Usage on no.wikipedia.org Plan (matematikk) Usage on pl.wiktionary.org plane Usage on sn.wikipedia.org Mutsendo Usage on ta.wikipedia.org தளம் (வடிவவியல்) Usage on th.wikipedia.org ระนาบ Usage on ur.wikipedia.org مستوی (ہندسہ) Usage on vi.wikipedia.org Mặt phẳng Usage on yi.wikipedia.org פלאך Metadata This file contains additional information, probably added from the digital camera or scanner used to create or digitize it. If the file has been modified from its original state, some details may not fully reflect the modified file. Create account Log in File Talk Main page Contents Featured content Current events Random article Donate to Wikipedia Wikipedia Shop Interaction Help About Wikipedia Community portal Recent changes Contact Wikipedia Toolbox Privacy policy About Wikipedia Disclaimers Mobile view
  2. MULTI LAYERED AND INDIVIDUAL CENTRIC  Figure 1-2: The proposed, individual-centric Information Commons (right panel) is somewhat analogous to a layered Geographical Information System (left panel). In both cases, the bottom layer defines the organization of all the overlays. However, in a GIS, any vertical line through the layers connects related snippets of information since all the layers are organized by geographical position. In contrast, data in each of the higher layers of the Information Commons will overlay on the patient layer in complex ways (e.g., patients with similar microbiomes and symptoms may have very different genome sequences). Source: FPA 2011 (left panel) Many parameters, dynamic, flexible, integrated From researchers, clinicians, patients