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Occupational asthma W.pongsak
scope ,[object Object],[object Object],[object Object],[object Object]
 
Type of occupational asthma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
Varients  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ORGANIC TOXIC DUST SYNDROME
Epidemiology   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Agent causing OA ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Pathophysiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cell mediated immunity ,[object Object],[object Object],[object Object],[object Object],[object Object]
H HDI induce prolipheration of  γδ T cell in OA patients
 
Increase production of IFN- γ  and IL-5 in OA patients
 
T cell in OA and OR increase both TH1&2 response and decrease Treg
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
Role of exposure ,[object Object],[object Object],[object Object]
Characteristic of antigen ,[object Object],[object Object],[object Object],[object Object]
Intensity of exposure ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Higher exposure to Fel d1 induce tolerance to cat allergen   and increase to specific IgG
Route of exposure ,[object Object],[object Object],[object Object]
Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],ACCP 2008
[object Object],[object Object],[object Object],[object Object],[object Object]
Spirometry and peakflow ,[object Object],[object Object],[object Object],[object Object],BYSSINOSIS
[object Object],[object Object],[object Object],[object Object],Genetic aspects
Gene associated with innate immunity and immune regulation ,[object Object],[object Object],[object Object],[object Object]
Gene asso withTH2 differentiation ,[object Object]
Gene asso with epithelium and mucosa ,[object Object],[object Object]
Gene asso with lung function ,airway remodeling ,[object Object],[object Object]
farmer sCD14 Acid anhydride HLA-DQB1 *0501 diiscyanate HLA-DQA1*0104 HLA-DQB1*0503 IL-4 α ,IL-13 GST,NAT Type of OA gene
 
 
 
N atural course ,[object Object],[object Object],[object Object],[object Object]
Management ,[object Object],[object Object],[object Object],[object Object],[object Object]
corticosteroid ,[object Object],[object Object],[object Object],[object Object]
Management ,[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory protective devices can decrease risk of occupational asthma from Anhydride
Management ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
OA caused by TDI can persistent worsening of PFT despite discontinue exposure
 
Management ,[object Object],[object Object],[object Object],[object Object],[object Object]
Allergen immunotherapy Latex allergy improve 24 pt.  (SCIT) Sastre et al improve 20 pt. (SCIT) Leynadier et al improve 4 pt.  (SCIT) Pereira et al improve 3 pt.  (or al) Toci et al improve 26 pt.  (SLIT) Cistero et al
Baker asthma Sea squirt allergy Laboratory animal Wood dust allergy improve 30 pt. (SCIT) Armentia et al improve -  Jyo et a l improve 1 pt. ( case report) Hansen et al improve 2 pt. (SCIT) Hinojosa et al
 
Prevention ,[object Object],[object Object],[object Object]
 
 
QUIZ ,[object Object]
[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FABED A. Bacillus Subtilis B. Tragacanth C. Grain Dust D. TDI E. Plicatic Acid F. Papain G. Psyllium ,[object Object],[object Object],[object Object],[object Object],[object Object]
1.2
conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object]
Thank you for your attention
agent
Good 3.25
2.108

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