1. (ATS6-APP03) THOMSON RUETERS CONTENT
USED IN PIPELINE PILOT
May 2013
Richard Lingard
Director of Partnership Development
Thomson Reuters Life Sciences

2. Me
Post Lunch Coma

3. Thomson Reuters?

4. Much more than news

5. LIFE SCIENCES DECISION SUPPORT
• IDRAC: regulatory
environment in 50+ global
markets
• Value add explanatory
documents and regulatory
Intelligence
• IDRAC: design global
regulatory submission / drug
approval strategies
• Newport: identify & evaluate
generic drug opportunities
Drug R&D Drug Pipeline
• Drug pipeline, deals, sales
forecasts, select patent &
scientific information
• Generic Drug Intelligence
• Current awareness and
competitive intelligence
• Drugs pipeline and patent
content for early stage
research
• Chemistry, genomics,
biomarkers & pathology data
Regulatory
• Understand disease, select
drug targets
• Demonstrate safety and
efficacy
• Design experiments
• Evaluate market
opportunities and
competitors’ pipelines
• Source and evaluate
licensing and acquisition
deals
Value
Propositio
n
Thomson Reuters
Integrity
‘By Scientists for Scientists’
Thomson Reuters
Pharma & Newport
Integrated business and
science content
IDRAC
Regulatory decision support
Disease Biology
• Manually curated Biological
Pathway maps
• Chemistry, genomics,
biomarkers & pathology data
• Target discovery and drug
repositioning
• Understand disease and
enrich your pathway insight
• Identify upstream and
downstream effects
• Integrate proprietary data
with public knowledge
Thomson Reuters
MetaCore
Biological Pathway and target
discovery

6. SOME OF OUR INFORMATION:
FROM DISCOVERY TO GENERICS
Lifecycle
Management
Discovery
Science
Pre-Clinical
Development
Phase I
Clinical
Phase II
Clinical
Phase III
Clinical
Regulatory
Review
Generic Drug Intelligence
11,000 launched drugs,
70 world markets
12,000 manufacturers
300 US patent challenges
Regulatory Intelligence
Enhanced regulatory data
covering 70 countries & region
Chemistry
2 million+ compounds
Structures, Reaction Sequences
Genetic Sequences
Over 32 million nucleic
and amino-acid sequences
Pipeline Drug Intelligence
37,000 drugs in R&D
status, indications, licensing
Scientific Journals
11,000+ peer-reviewed
Journals, 12,000 Conferences
Corporate Intelligence
Coverage of 40,000 companies
involved in Drug Development
Intellectual Property
Value added patents from
92 countries. Abstracted 30 hours
after publication
Benchmarks & Services
Gold Standard Pharma R&D
Benchmarks and Services
Biomarkers
6,000+ Biomarkers with
over 200,000 uses
Healthcare Data
Patient data & clinical decision
support information
Pathway Analytics
1,015+ Canonical Pathways
980+ Network Maps

7. CORTELLIS IS AN OPEN PLATFORM –
SUPPORTING INFORMATION FLOW
Cortellis
Platform
Cortellis for
Informatics Web
Services APIs
Cortellis for
Information Integration
Secure hosting
“Push” information onto the
platform to consume
alongside other databases
and/or annotate and tag
content for sharing
“Pull” information
from APIs directly or
via partners
technologies to
integrate into day-to-
day workflows
Professional Services
team

8. WEB SERVICES APIs
• Industry-Standard way to make structured, “Deep
Web” content available to users
– Works through firewalls
– Many tools available to consume APIs
• Two common protocols, we support both
– REpresentional State Transfer (REST)
– Simple Object Access Protocol (SOAP)

9. PARTNERSHIP ECOSYSTEM
“To enable better decision making for our customers by making Thomson
Reuters knowledge available at the point of need.”
Thomson Reuters’ content should be seamlessly integrated into our clients
work flow at the point where it adds most value.
Relevant knowledge should be presented at the pertinent time clearing the way
for our clients to make more informed decisions.

10. CURRENT SIGNIFICANT PARTNERS
Workflow automation
Biology
ELN
Visualisation
IP Management
Text mining
Info sharing
Content integration

11. THOMSON REUTERS CORTELLIS®
PARTNER ECOSYSTEM
Cortellis technology integrations enable access to content from anywhere.
11

12. ACCELRYS
Thomson Reuters content in Pipeline Pilot.
• Automated analysis of Thomson Reuters content combined with data
from many sources, enables researchers to explore, visualize, and report
research results fast.
• Content seamlessly into the Accelrys electronic lab notebooks
• Use the quality of Thomson Reuters structured content to validate the
aggregated disparate research data that Pipeline Pilot can generate
Pipeline Pilot addresses the modeling and simulation, informatics, and scientific
businesses intelligence needs of research and development organizations.
It can manage scientific information and rapidly adjust workflows, to optimize
research cycles, and respond to changing market conditions.

13. API PARTNER CONNECTIONS ROADMAP
API Current partners
Investigational Drugs CI Drugs, Deals, Forecasts,
Companies, Diseases
Targets Active Targets
Analytics Drug Development, Trials,
Patents
Patents CI Patents
(
Trials, Literature, Press
Releases, Conferences
Regulatory Documents, Guidelines,
Global Comparisons, Drug
Approvals
Drug Design SI Drugs, PK/PD,
Experimental Pharmacology
Ontologies SI & CI Ontologies, Auto-
Indexing
Omics Genes, Proteins,
Biomolecules, Interactions,
Pathways
Omics Analytics
Gene Variants
Biomarkers
These partners connect to all the API’s
*
*
*
**
*
*
Soon to be released

14. API ROADMAP
API Current Q2 2013 Q3 2013 Q4 2013
Investigational Drugs CI Drugs, Deals, Forecasts,
Companies, Diseases
Targets Active Targets New version - Active &
Putative Targets, improved
search
Analytics Drug Development, Trials,
Patents
Patents CI Patents DWPI
Clinical Trials, Literature, Press
Releases, Conferences
Enhanced Trials Coverage Segmented Trial Outcomes
Regulatory Documents, Guidelines,
Global Comparisons, Drug
Approvals
Drug Design SI Drugs, PK/PD,
Experimental Pharmacology
DDIs Experimental Models
Ontologies SI & CI Ontologies, Auto-
Indexing
Enhanced auto-indexing
Omics Genes, Proteins,
Biomolecules, Interactions,
Pathways
V2
Omics Analytics Pathway Enrichment, List-
processing, Network-
building
Gene Variants Variant-Disease/Biomarker
content
V2
Biomarkers Biomarkers

15. CURRENTLY AVAILABLE – 1/3
• Investigational Drugs
– Drug, Company, Deals & Forecasts Information from
Cortellis and Disease Briefings from Integrity
– Text and/or structure searchable
• Targets
– Target information from Integrity and MetaCore
• Ontologies
– Synonym mappings for drugs, diseases, targets & actions
– Integrity & Cortellis (CI) taxonomies
– Auto indexing text to Cortellis vocabularies

16. CURRENTLY AVAILABLE – 2/3
• Patents
– Patent Information from Cortellis
– Text and/or structure searchable
• Clinical
– Trials, Press-Releases & Meetings content from Cortellis
– Literature (DDF) content from Cortellis (text/structure
searchable)
• Analytics
– Aggregated trial information (including adverse events),
patents & pipeline data from Cortellis

17. CURRENTLY AVAILABLE – 3/3
• Regulatory
– Regulatory Reports, Global Regulatory Comparisons from
IDRAC
• Drug Design
– Core Drugs & Biologics, Experimental Pharmacology and
PK information from Integrity
– Structure and text searchable
• Omics
– Biological objects, interactions & pathways from MetaCore
• Gene Variants
– Variant-disease and Variant-response data from Integrity
& MetaBase

18. API SUPPORT
• Support site at
http://developercenter.thomsonreuters.com
• Documentation
• Sample Code
• Tips & Tricks
• Support community

21. THOMSON RUETERS CONTENT USED IN
PIPELINE PILOT
May 2013
Michael Hughes
Consultant, Text Analytics (Technical Consulting Services)
Thomson Reuters Life Sciences

22. Pipeline Pilot Case Studies
• Accessing Thomson Reuters’ APIs to import and
process data
• PP Reporting Collection to create interactive views
from XML data
• Using the TR Investigational Drugs API to highlight
relationships between drugs, indications and
mechanisms of action
• PP Text Analytics Collection to identify Scientific
Key Opinion Leaders from Web of Science content

23. Interactive reports from Thomson Reuters
Investigational Drugs API
...ls-api-ws/ws/rs/diseasebriefings-v1/diseasebriefing/2/

24. Interactive reports from Thomson Reuters
Investigational Drugs API

25. Investigational Drugs API: New uses for
existing drugs?
• Drug names
• Primary Indications
• Mechanisms of Action
• Company Information
• Sales Data
• Highest Phase

26. Investigational Drugs API interactive network
visualisation: Live Demo
• http://10.226.21.110/CytoscapeWeb/InvestigationalDrugs.html

27. Thomson Reuters Web of Science: Analysing
Scientific Key Opinion Leaders

28. Thomson Reuters Web of Science: Analysing
Scientific Key Opinion Leaders
• Extract metrics per author e.g.
– Total Number of Journal Publications (as first/last author)
– Conference Publications
– Total Times Cited
– Number of Collaborators
– Author keywords
– Institution Address
– Country
• Build network files
– Author A to Author B
– Collaboration Frequency

29. Thomson Reuters Web of Science: Analysing
Scientific Key Opinion Leaders
• Major challenge: Author Disambiguation

30. Thomson Reuters Web of Science: Analysing
Scientific Key Opinion Leaders

31. Questions?