Nanoparticle sampling in academic labs

University of North Carolina at Chapel Hill Catherine Brennan NANOPARTICLE AIR MONITORING IN A UNIVERSITY RESEARCH SETTING

[object Object],[object Object],[object Object],[object Object],[object Object],Overview

Nanotechnology at UNC Chapel Hill ,[object Object],[object Object],[object Object],[object Object]

Nanomaterial Risk Level (NRL) NRL Type of Nanomaterial Practices Engineering Controls Personal Protective Equipment (PPE) 1 Polymer matrix ,[object Object],[object Object],[object Object],Fume hood or biological safety cabinet (Class II Type A1, A2 vented via a thimble connection, B1 or B2) Standard PPE (lab coat, gloves, safety glasses with side shields) 2 Liquid dispersion ,[object Object],[object Object],[object Object],[object Object],Fume hood or biological safety cabinet (Class II Type A1, A2 vented via a thimble connection, B1 or B2) or approved vented enclosure (e.g., Flow Sciences vented balance safety enclosure [VBSE]) ,[object Object],[object Object],[object Object],3 Dry powders or aerosols ,[object Object],[object Object],[object Object],Fume hood or biological safety cabinet (Class II Type A1, A2 vented via a thimble connection, B1 or B2) or approved vented enclosure (e.g., Flow Sciences vented balance safety enclosure [VBSE]). HEPA filtered exhaust preferred for fume hoods containing particularly “dusty” operations. NRL-2 practice plus: N95 respirators are required if work operation must be done outside of containment 4 Dry Powders or aerosols of parent materials with known toxicity or hazards ,[object Object],[object Object],[object Object],Fume hood or biological safety cabinet (Class II Type B1 or B2) or glove box or approved vented enclosure (e.g., Flow Sciences vented balance safety enclosure [VBSE]). HEPA filtered exhaust with Bag-In/Bag-Out capability preferred for hoods, BSCs, and gloveboxes. NRL-3 practice plus: Need determined and respirator selected with reference to the engineering controls in use and potential for aerosol generation

Nanotechnology Safety Policy(2010) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nanotechnology Safety Policy ,[object Object],[object Object],[object Object],[object Object],[object Object]

NIOSH Guidance Document ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

UNC Direct Read Instruments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

UNC Direct Read Instruments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nanomedicine Clean Room ,[object Object],[object Object],BSL 2 hood Walk in hood Bench Chemical Hood refrige. cabinet freezer cabinet Controlled humidity room On top of shelf refrige. Bead Harvester

Clean Room – CPC Data ,[object Object],[object Object],[object Object],Mean (#/cm³) 14.5 Min. (#/cm³) 11.0 Max. (#/cm³) 28.0 Std. Dev. (#/cm³) 2.29 Sample Time (secs) 6420 Time (secs) #/cm 3

Clean Room – OPC Data Time (hr:min:secs) Particles/Liter Background (03/22/11 )

Clean Room – CPC Data ,[object Object],[object Object],Background 03/24/11 03/29/11 Date Start/End Time Range (#/cm 3 ) Mean (#/cm 3 ) Averaging Interval (seconds) Sample Length (hr:min) 3/22/11 1:46pm/3:33pm 11-28 14.5 60 1:47 3/24/11 8:35am/12:29pm 4-35 10.2 60 3:54 3/29/11 8:37am/2:34pm 6-97 17.0 60 5:57

Clean Room - OPC ,[object Object],[object Object],03/24/11 (OPC Data) 03/24/11 (CPC Data)

Clean Room ,[object Object],[object Object],BSL 2 hood Walk in hood Bench Chemical Hood refrige. cabinet freezer cabinet Controlled humidity room refrige. Bead Harvester

Clean Room – CPC Data (3/31) ,[object Object],[object Object],03/31/11 Date Start/End Time Range (#/cm 3 ) Mean (#/cm 3 ) Averaging Interval (seconds) Sample Length (hr:min) 3/22/11 1:46pm/3:33pm 11-28 14.5 60 1:47 3/31/11 8:47am/1:58pm 2-9300 492.6 60 5:11

Clean Room – OPC (3/31) ,[object Object],[object Object],[object Object],03/31/11 (CPC Data)

Future - Aerosolization Research ,[object Object],[object Object],[object Object]

Titanium Dioxide ,[object Object],[object Object],[object Object],[object Object],[object Object]

Future TiO 2 Monitoring Plans ,[object Object],[object Object],[object Object],[object Object],[object Object]

Future TiO 2 Monitoring Plans ,[object Object],[object Object],[object Object]

Carbon Nanotubes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Challenges at a University ,[object Object],[object Object],[object Object],[object Object],[object Object]

Challenges at a University - EHS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Good News ,[object Object],[object Object],[object Object],[object Object]

What University’s Need ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Contact Information:

Condensation Particle Counter ,[object Object],[object Object],[object Object],[object Object],* Information taken from TSI website

Optical Particle Counter ,[object Object],[object Object],[object Object],* Information taken from TSI website

Diffusion Charger (Surface Area) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],* Information taken from TSI website

Nanoparticle sampling in academic labs

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